SINCE World War II, medical science has progressed to a stage where competitive medications are available to treat precisely the same ailment in numerous people. It’s not nearly brands (that is a trade issue) but generic drugs (that is a scientific issue). Within this report, we shall glance at the various factors that decide the selection of a certain drug.

Safety: The following sub-criteria have to be considered beneath the criterion of safety:

* Acute therapeutic index: If your patient’s condition is acute, how effective is really a particular drug even if they have certain side-effects as long as the acuteness from the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but feature the possible side-effect of addiction.

* Long-term safety: drug directory might be safe in short-term treatment, but wait, how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the case of prolonged use.

* Drug-drug interaction risk: Medicine is chemicals, and lots of chemicals reply to make a different chemical, which has an effect that will harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.

Drug-drug interaction risk is of 2 types:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of the other, have certain effects one or higher body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is dependent upon for its metabolism. This makes an increase in the side-effects of Lexapro.

· Pharmacodynamic: Here, 2 or more drugs actually generate the same impact on precisely the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both drugs are more intense.

Tolerability: A drug might be effective but not tolerable by all patients. Example: Allergies to specific drugs in some people. Short-term and long-term tolerability should be taken into consideration. Efficacy: A drug isn’t equally effective in all patients. As an example, some patients with depression or panic disorders experience respite from escitalopram, but there are several who don’t, who therefore should be prescribed a different anti-depressant. The speed of start of therapeutic action is a vital the answer to be regarded too.

Cost: Cost doesn’t imply the expense of purchase of a certain medicine alone. It must also cover the expense of treatment of a complication that will arise from utilizing a different drug. Example: Inside a individual that insists on taking alcohol and yet has to be treated for depression is usually administered an SSRI drug as these drugs don’t potentiate the end results of alcohol, whereas another gang of anti-depressants (like tricyclics) could cause a fresh overuse injury in such patients, which could have to have a various and expensive treatment. Therefore, it’s safer to prescribe the more costly escitalopram instead of a cheaper tricyclic in this patients.

Simplicity of treatment: The easiest mode of administration is preferred. If you have an option between an injection and oral administration, aforementioned is preferred when the efficacy of both modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are an important factor to determine simplicity of treatment.
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