SINCE World War II, medical science has progressed to a stage where competitive medications are around to treat exactly the same ailment in numerous people. It’s not almost brands (the industry trade issue) but generic drugs (the industry scientific issue). On this report, we shall look at the various factors that decide selecting a specific drug.

Safety: These sub-criteria should be considered underneath the criterion of safety:

* Acute therapeutic index: If the patient’s condition is acute, how effective is often a particular drug even if it’s certain side-effects providing the acuteness of the condition is lowered? Example: narcotic pain-killers work well in healing pain but have the potential side-effect of addiction.

* Long-term safety: drug may be safe in short-term treatment, so how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the event of prolonged use.

* Drug-drug interaction risk: Drugs are chemicals, and several chemicals react to produce a different chemical, which has an effect that may harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.

Drug-drug interaction risk is of 2 types:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from the other, have certain effects one or more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is determined by for its metabolism. This leads to an increase in the side-effects of Lexapro.

· Pharmacodynamic: Here, several drugs actually generate the same relation to exactly the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of both the medicine is more intense.

Tolerability: A medication may be effective although not tolerable by all patients. Example: Allergies to a particular drugs in some people. Short-term and long-term tolerability have to be taken into consideration. Efficacy: A medication isn’t equally great at all patients. For instance, some patients with depression or anxiety disorders experience relief from escitalopram, but there are many that don’t, who therefore have to be prescribed a different anti-depressant. The interest rate of start of therapeutic action is a vital step to be regarded too.

Cost: Cost doesn’t imply the expense of buying a certain medicine alone. It must also cover the expense of management of a complication that may arise while using a different drug. Example: In the person who insists on taking alcohol nevertheless needs to be treated for depression is normally administered an SSRI drug because these drugs don’t potentiate the consequences of alcohol, whereas another group of anti-depressants (such as tricyclics) could cause a new overuse injury in such patients, which will have to have a various and expensive treatment. Therefore, it’s safer to prescribe the more costly escitalopram rather than cheaper tricyclic in such patients.

Simple treatment: The simplest mode of administration is preferred. If you have a selection between an injection and oral administration, the second is preferred in the event the efficacy of both the modes is comparable. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key point to determine simple treatment.
For details about drug go to see the best internet page: read more