SINCE The second world war, medical science has progressed into a stage where competitive medications are around for treat the identical ailment in different people. This is not almost brands (which is a trade issue) but generic drugs (which is a scientific issue). On this report, we shall look at the various factors that decide selecting a certain drug.

Safety: The subsequent sub-criteria has to be considered under the criterion of safety:

* Acute therapeutic index: If your patient’s condition is acute, how effective is really a particular drug regardless of whether it has certain side-effects so long as the acuteness from the condition is lowered? Example: narcotic pain-killers work well in healing pain but come with the possible side-effect of addiction.

* Long-term safety: medication could be safe in short-term treatment, so how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in the case of prolonged use.

* Drug-drug interaction risk: Medicine is chemicals, and a lot of chemicals react to develop a different chemical, that have an effect which could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.

Drug-drug interaction risk is of two sorts:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of one another, have certain effects one or higher body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by because of its metabolism. This makes more the side-effects of Lexapro.

· Pharmacodynamic: Here, a couple of drugs actually produce the same impact on the identical organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the prescription medication is more intense.

Tolerability: A medicine could be effective and not tolerable by all patients. Example: Allergies to particular drugs in certain people. Short-term and long-term tolerability have to be looked at. Efficacy: A medicine isn’t equally great at all patients. As an example, some patients with depression or panic attacks experience relief from escitalopram, but there are lots of that don’t, who therefore have to be prescribed another anti-depressant. The pace of start of therapeutic action is a vital the answer to be considered too.

Cost: Cost does not mean the cost of acquisition of a particular medicine alone. It should also cover the cost of management of a complication which could arise by using another drug. Example: In the individual that insists on taking alcohol yet needs to be treated for depression is generally administered an SSRI drug since these drugs don’t potentiate the end results of alcohol, whereas another band of anti-depressants (such as tricyclics) could cause a fresh overuse injury in such patients, which will require a various and expensive treatment. Therefore, it’s easier to prescribe the more expensive escitalopram instead of a cheaper tricyclic in this patients.

Simplicity of treatment: The easiest mode of administration is preferred. If you find an alternative between a shot and oral administration, rogues is preferred if your efficacy of the modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key point to make a decision simple treatment.
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