SINCE World war 2, medical science has progressed to a stage where competitive medications are available to treat the identical ailment in different people. It’s not pretty much brands (which is a trade issue) but generic drugs (which is a scientific issue). With this report, we shall look at the various factors that decide the selection of a selected drug.

Safety: These sub-criteria have to be considered beneath the criterion of safety:

* Acute therapeutic index: In the event the patient’s condition is acute, how effective is a particular drug even when it’s got certain side-effects providing the acuteness with the condition is lowered? Example: narcotic pain-killers work well in healing pain but come with the possibility side-effect of addiction.

* Long-term safety: medicine directory might be safe in short-term treatment, so how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the case of prolonged use.

* Drug-drug interaction risk: Medicines are chemicals, and many chemicals respond to make a different chemical, that have an effect which could harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.

Drug-drug interaction risk is of two kinds:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of each other, have certain effects using one or even more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon for the metabolism. This makes a rise in the side-effects of Lexapro.

· Pharmacodynamic: Here, a couple of drugs actually create the same effect on the identical organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of both the medicine is more serious.

Tolerability: A drug might be effective although not tolerable by all patients. Example: Allergies to certain drugs in certain people. Short-term and long-term tolerability have to be taken into consideration. Efficacy: A drug is just not equally great at all patients. For instance, some patients with depression or anxiety disorders experience reduced escitalopram, but there are several who don’t, who therefore have to be prescribed an alternative anti-depressant. The pace of oncoming of therapeutic action is a crucial factor to be looked at too.

Cost: Cost does not mean the expense of buying some medicine alone. It ought to also cover the expense of treatments for a complication which could arise by using an alternative drug. Example: Within a individual that insists on taking alcohol yet needs to be treated for depression is often administered an SSRI drug because they drugs don’t potentiate the results of alcohol, whereas another number of anti-depressants (for example tricyclics) might cause a fresh condition in such patients, which may require a different and expensive treatment. Therefore, it’s easier to prescribe the more expensive escitalopram instead of a cheaper tricyclic in these patients.

Simple treatment: The easiest mode of administration is preferred. When there is an option between a shot and oral administration, aforementioned is preferred if your efficacy of both the modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are an important factor to decide simplicity of treatment.
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