SINCE Wwii, medical science has progressed to a stage where competitive medications are available to treat the identical ailment in numerous people. This is not almost brands (that is a trade issue) but generic drugs (that is a scientific issue). With this report, we shall consider the various factors that decide selecting a specific drug.

Safety: The next sub-criteria has to be considered under the criterion of safety:

* Acute therapeutic index: When the patient’s condition is acute, how effective can be a particular drug even if it’s got certain side-effects as long as the acuteness with the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but come with the opportunity side-effect of addiction.

* Long-term safety: medicine could possibly be safe in short-term treatment, but wait, how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the case of prolonged use.

* Drug-drug interaction risk: Prescription medication is chemicals, and lots of chemicals respond to make a different chemical, that have an effect that will harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.

Drug-drug interaction risk is of two kinds:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from the other person, have certain effects on a single or even more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends upon for the metabolism. This will cause a boost in the side-effects of Lexapro.

· Pharmacodynamic: Here, a couple of drugs actually produce the same influence on the identical organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both the medicines are more intense.

Tolerability: A drug could possibly be effective however, not tolerable by all patients. Example: Allergies to specific drugs in some people. Short-term and long-term tolerability must be looked at. Efficacy: A drug is just not equally efficient at all patients. By way of example, some patients with depression or anxiety disorders experience respite from escitalopram, but there are numerous that do not, who therefore must be prescribed a different anti-depressant. The pace of onset of therapeutic action is a factor to be regarded as too.

Cost: Cost does not necessarily mean the price of buying a certain medicine alone. It ought to also cover the price of treatments for a complication that will arise from using a different drug. Example: In the person who insists on taking alcohol but needs to be treated for depression is generally administered an SSRI drug because they drugs don’t potentiate the end results of alcohol, whereas another gang of anti-depressants (such as tricyclics) could cause a new problem in such patients, which may require a various and expensive treatment. Therefore, it’s easier to prescribe the more expensive escitalopram rather than cheaper tricyclic in these patients.

Simplicity of treatment: The simplest mode of administration is preferred. If there is a choice between a shot and oral administration, the latter is preferred when the efficacy of both the modes is comparable. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are key point to make a decision simple treatment.
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