SINCE Wwii, medical science has progressed to a stage where competitive medications are available to treat exactly the same ailment in different people. This isn’t pretty much brands (that is a trade issue) but generic drugs (that is a scientific issue). Within this report, we shall look at the various factors that decide the selection of a particular drug.

Safety: The subsequent sub-criteria must be considered underneath the criterion of safety:

* Acute therapeutic index: In the event the patient’s condition is acute, how effective is often a particular drug even though it’s certain side-effects providing the acuteness in the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but feature the opportunity side-effect of addiction.

* Long-term safety: directory might be safe in short-term treatment, but exactly how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in the event of prolonged use.

* Drug-drug interaction risk: Prescription medication is chemicals, and a lot of chemicals reply to make a different chemical, which has an effect that could harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.

Drug-drug interaction risk is of two sorts:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from the other person, have certain effects on one or higher body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon because of its metabolism. This makes a rise in the side-effects of Lexapro.

· Pharmacodynamic: Here, two or more drugs actually generate the same relation to exactly the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both prescription medication is more intense.

Tolerability: A drug might be effective however, not tolerable by all patients. Example: Allergies to specific drugs in most people. Short-term and long-term tolerability should be considered. Efficacy: A drug just isn’t equally good at all patients. For example, some patients with depression or panic attacks experience relief from escitalopram, but there are many that don’t, who therefore should be prescribed an alternative anti-depressant. The rate of onset of therapeutic action is a vital factor to be regarded as too.

Cost: Cost doesn’t imply the expense of buying a certain medicine alone. It will also cover the expense of treatments for a complication that could arise from using an alternative drug. Example: Within a one who insists on taking alcohol yet should be treated for depression is usually administered an SSRI drug because these drugs don’t potentiate the consequences of alcohol, whereas another gang of anti-depressants (like tricyclics) might cause a whole new overuse injury in such patients, which will have to have a various and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram rather than a cheaper tricyclic in these patients.

Simple treatment: The easiest mode of administration is preferred. When there is a choice between a shot and oral administration, the latter is preferred in the event the efficacy of both modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are a key factor to determine simple treatment.
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