SINCE Wwii, medical science has progressed into a stage where competitive medications are available to treat the identical ailment in several people. This is simply not almost brands (the industry trade issue) but generic drugs (the industry scientific issue). Within this report, we shall glance at the various factors that decide picking a a specific drug.

Safety: These sub-criteria must be considered under the criterion of safety:

* Acute therapeutic index: In the event the patient’s condition is acute, how effective is really a particular drug even if it has certain side-effects as long as the acuteness of the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but have the possible side-effect of addiction.

* Long-term safety: medication could be safe in short-term treatment, but wait, how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in case of prolonged use.

* Drug-drug interaction risk: Medicine is chemicals, and several chemicals respond to develop a different chemical, that have an effect that may harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.

Drug-drug interaction risk is of two kinds:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of one another, have certain effects on one or higher body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by for the metabolism. This causes an increase in the side-effects of Lexapro.

· Pharmacodynamic: Here, two or more drugs actually generate the same effect on the identical organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of both medicines are more intense.

Tolerability: A medication could be effective and not tolerable by all patients. Example: Allergies to certain drugs in most people. Short-term and long-term tolerability have to be taken into account. Efficacy: A medication is just not equally efficient at all patients. For instance, some patients with depression or panic disorders experience respite from escitalopram, but there are numerous that do not, who therefore have to be prescribed another anti-depressant. The rate of beginning of therapeutic action is a the answer to be regarded as too.

Cost: Cost doesn’t imply the price tag on purchase of some medicine alone. It ought to also cover the price tag on management of a complication that may arise while using another drug. Example: In the person who insists on taking alcohol and yet should be treated for depression is often administered an SSRI drug because these drugs don’t potentiate the results of alcohol, whereas another band of anti-depressants (for example tricyclics) can cause a whole new condition in such patients, which may need a various and expensive treatment. Therefore, it’s preferable to prescribe the more costly escitalopram rather than cheaper tricyclic such patients.

Simple treatment: The best mode of administration is preferred. If you have a choice between an injection and oral administration, rogues is preferred when the efficacy of both modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are an important factor to determine simplicity of treatment.
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