Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors depending on each SARM’s chemical structure. Because of this, SARMs bring about anabolic cellular activity while avoiding a lot of the side effects of now available steroids. SARMs are already studied in the treatment of cancers of the breast and cachexia and have also been used as performance-enhancing agents. Here, we evaluate and summarize the current literature on SARMs.

Aim
To present the history, mechanisms, current and potential clinical applications, as well as risks and great things about SARMs.

Methods
A literature review was performed in MEDLINE with all the terms selective androgen receptor modulator, hypogonadism, cachexia, cancers of the breast, benign prostatic hyperplasia, libido, and lean body mass. Both preliminary research and scientific studies were included.

Main Outcome Measure
To perform a review of peer-reviewed literature.

Results
Although there are presently no U.S. Drug and food Agency-approved indications for SARMs, investigators are going through the potential uses of these compounds. Preliminary research has centered on the pharmacokinetics and pharmacodynamics of such agents, demonstrating good availability having a paucity of drug interactions. Early clinical tests have demonstrated potential purposes of SARMs inside the treating cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancer, with good success.

Conclusion
SARMs have several possible clinical applications, with promise to the safe use in the treating cachexia, BPH, hypogonadism, breast cancer, and prostate cancer.

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