SINCE World War II, medical science has progressed with a stage where competitive medications are available to treat precisely the same ailment in various people. This is not almost brands (that is a trade issue) but generic drugs (that is a scientific issue). On this report, we shall look at the various factors that decide the selection of a specific drug.

Safety: The following sub-criteria should be considered underneath the criterion of safety:

* Acute therapeutic index: If the patient’s condition is acute, how effective is often a particular drug regardless of whether it’s certain side-effects so long as the acuteness in the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but come with the possibility side-effect of addiction.

* Long-term safety: medicationdirectory.com might be safe in short-term treatment, so how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in case of prolonged use.

* Drug-drug interaction risk: Prescription medication is chemicals, and a lot of chemicals reply to make a different chemical, that have an effect that will harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.

Drug-drug interaction risk is of two types:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from the other person, have certain effects on a single or even more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon because of its metabolism. This leads to an increase in the side-effects of Lexapro.

· Pharmacodynamic: Here, several drugs actually generate the same impact on precisely the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both the prescription medication is more serious.

Tolerability: A medicine might be effective but not tolerable by all patients. Example: Allergies to particular drugs in most people. Short-term and long-term tolerability need to be taken into account. Efficacy: A medicine just isn’t equally efficient at all patients. For instance, some patients with depression or panic attacks experience respite from escitalopram, but there are lots of who don’t, who therefore need to be prescribed some other anti-depressant. The rate of beginning of therapeutic action is a crucial key to be regarded as too.

Cost: Cost doesn’t imply the price tag on acquiring a certain medicine alone. It must also cover the price tag on treating a complication that will arise by using some other drug. Example: Inside a individual who insists on taking alcohol and yet must be treated for depression is generally administered an SSRI drug as these drugs don’t potentiate the effects of alcohol, whereas another group of anti-depressants (for example tricyclics) can cause a new problem in such patients, which may need a different and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram as opposed to a cheaper tricyclic in these patients.

Simple treatment: Most effective mode of administration is preferred. When there is a selection between an injection and oral administration, aforementioned is preferred if your efficacy of both the modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are key point to make a decision simple treatment.
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